Keys
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Keys are pickups that are always obtained from a Key Chest after an Elite or a Boss fight. Unlike other pickups, keys do not disappear when a run ends, allowing you to use them even if you die.
Usage
Keys are used to unlock new content, be it weapons, abilities, melee weapons, perks, weapon mods, or grenade mods. It requires 3 Keys to be used at the Key Totem, where then you can start a new run with your new unlock.